SCHEMBL3101729

SCHEMBL3101729

C=C(C)C(=O)OCCCC([SiH3])(c1ccccc1)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.47
POLB P06746 1/20 0.47
APEX1 P27695 1/20 0.47
HTT P42858 1/20 0.47
TSHR P16473 4/20 0.44
THRB P10828 1/20 0.38
ELANE P08246 1/20 0.36
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CYP3A4 P08684 3/20 0.34
CYP2D6 P10635 3/20 0.34
LMNA P02545 2/20 0.34
CYP1A2 P05177 2/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
PPARA Q07869 1/20 0.34
NFKB1 P19838 1/20 0.34
SCN1A P35498 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17320926 0.85 TDP1 (0.49) TDP1POLBAPEX1HTTTSHR
SCHEMBL5853805 0.84 ALDH1A1 (0.47) TDP1POLBAPEX1HTTTSHR
SCHEMBL15404816 0.83 TDP1 (0.45) TDP1POLBAPEX1HTTTSHR
SCHEMBL7872447 0.82 TDP1 (0.44) TDP1POLBAPEX1HTTTSHR
SCHEMBL28552216 0.79 POLB (0.44) TDP1POLBAPEX1HTTTSHR
SCHEMBL24312367 0.78 TDP1 (0.48) TDP1POLBAPEX1HTTTSHR
SCHEMBL28173347 0.78 TDP1 (0.51) TDP1POLBAPEX1HTTTSHR
Hydrochloric Acid SCHEMBL28129149 0.78 POLB (0.42) TDP1POLBAPEX1HTTTSHR
SCHEMBL234086 0.77 POLB (0.41) TDP1POLBAPEX1HTTTSHR
SCHEMBL23321949 0.77 TSHR (0.53) TDP1POLBAPEX1HTTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7495052-B2 Method for the production of polymerized nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility BAUSCH & LOMB INCORPORATED (US) 2009-02-24 US claimed
EP-1444239-B1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILYL MONOMERS BAUSCH & LOMB (US) 2008-12-24 EP claimed
EP-1448571-B1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE MONOFUNCTIONAL MACROMONOMERS BAUSCH & LOMB (US) 2008-05-21 EP claimed
US-7169874-B2 High refractive index polymeric siloxysilane compositions BAUSCH & LOMB INCORPORATED (US) 2007-01-30 US claimed
WO-2006137855-A2 METHOD FOR THE PRODUCTION OF POLYMERIZED NANOPARTICLES AND MICROPARTICLES BY TERNARY AGENT CONCENTRATION AND TEMPERATURE ALTERATION INDUCED IMMISCIBILITY BAUSCH & LOMB INCORPORATED (US) 2006-12-28 WO claimed
US-20060057222-A1 Method for the production of polymerized nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility BAUSCH & LOMB INCORPORATED 2006-03-16 US claimed
US-6908978-B2 High refractive index polymeric siloxysilane compositions BAUSCH & LOMB INCORPORATED (US) 2005-06-21 US claimed
US-20050085611-A1 High refractive index aromatic-based siloxane difunctional macromonomers BAUSCH & LOMB MEXICO, S.A. DE C.V. (MX) 2005-04-21 US claimed
EP-1519968-A1 LOW WATER CONTENT HIGH REFRACTIVE INDEX, FLEXIBLE, POLYMERIC COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2005-04-06 EP claimed
US-6852793-B2 Low water content, high refractive index, flexible, polymeric compositions BAUSCH & LOMB INCORPORATED (US) 2005-02-08 US claimed
US-20030144451-A1 High refractive index aromatic-based siloxane difunctional macromonomers BAUSCH HEALTH US, LLC 2003-07-31 US claimed
US-20030139557-A1 High refractive index aromatic-based siloxane monofunctional macromonomers PRECISION DERMATOLOGY, INC. 2003-07-24 US claimed
US-20030109661-A1 High refractive index polymeric siloxysilane compositions BAUSCH HEALTH US, LLC 2003-06-12 US claimed
US-20030105255-A1 High refractive index aromatic-based silyl monomers BAUSCH HEALTH, CANADA INC. / SANTE BAUSCH, CANADA INC. (CA) 2003-06-05 US claimed
US-20030100697-A1 High refractive index polymeric siloxysilane compositions SALIX PHARMACEUTICALS, INC. 2003-05-29 US claimed
WO-2003040154-A1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE DIFUNCTIONAL MACROMONOMERS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed
WO-2003040155-A1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILOXANE MONOFUNCTIONAL MACROMONOMERS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed
WO-2003040158-A1 HIGH REFRACTIVE INDEX POLYMERIC SILOXYSILANE COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed
WO-2003040152-A1 HIGH REFRACTIVE INDEX AROMATIC-BASED SILYL MONOMERS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed
WO-2003040157-A1 HIGH REFRACTIVE INDEX POLYMERIC SILOXYSILANE COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO claimed