Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.48 |
| ▸ | TPMT | P51580 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.46 |
| ▸ | CTRC | Q99895 | 2/20 | 0.46 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28262749 | 0.88 | ALDH1A1 (0.46) | ALOX15TSHRALDH1A1NR4A2SRD5A2 | |
| SCHEMBL11816323 | 0.88 | ALDH1A1 (0.46) | ALOX15TSHRALDH1A1NR4A2SRD5A2 | |
| SCHEMBL11467697 | 0.86 | TSHR (0.74) | ALOX15TSHRALDH1A1NR4A2SRD5A2 | |
| SCHEMBL28951143 | 0.86 | SRD5A2 (0.58) | TSHRALDH1A1SRD5A2 | |
| SCHEMBL1950244 | 0.83 | CA12 (0.48) | ALOX15TSHRALDH1A1SRD5A2TPMT | |
| SCHEMBL7945362 | 0.82 | ESR1 (0.56) | SRD5A2 | |
| SCHEMBL2142442 | 0.82 | PLA2G10 (0.53) | TSHRSRD5A2DAO | |
| SCHEMBL27692120 | 0.81 | CTRC (0.57) | ALOX15TSHRALDH1A1NR4A2SRD5A2 | |
| SCHEMBL11673315 | 0.81 | SRD5A2 (0.62) | TSHRALDH1A1SRD5A2 | |
| SCHEMBL28029673 | 0.81 | PPARA (0.49) | NR4A2SRD5A2MRGPRX4MEP1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106459062-A | Substituted [1,2,4] triazolo [1,5-a ] pyrimidin-7-yl compounds as PDE2 inhibitors | 达特神经科学(开曼)有限公司 | 2017-02-22 | — | — | CN | claimed |
| CN-106459062-A | Substituted [1,2,4] triazolo [1,5-a ] pyrimidin-7-yl compounds as PDE2 inhibitors | 达特神经科学(开曼)有限公司 | 2017-02-22 | — | — | CN | disclosed |