Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 4/20 | 0.34 |
| ▸ | PPARA | Q07869 | 4/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17201231 | 0.89 | LMNA (0.38) | PTGER4ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL28131930 | 0.86 | USP2 (0.42) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL28841115 | 0.81 | VDR (0.40) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL17201299 | 0.80 | LMNA (0.39) | PTGER4ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL17201007 | 0.75 | SAE1 (0.41) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL17201130 | 0.74 | LMNA (0.40) | PTGER4ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL28132718 | 0.74 | RXRA (0.44) | PPARARXRA | |
| SCHEMBL17205570 | 0.73 | CHRM1 (0.44) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28841022 | 0.72 | CHRM1 (0.44) | ALDH1A1MAPTMEN1KMT2APPARG | |
| SCHEMBL17201017 | 0.72 | EPHX2 (0.36) | PTGER4ALDH1A1MAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106536508-A | ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE | 武田药品工业株式会社 | 2017-03-22 | — | — | CN | disclosed |