SCHEMBL28133754

SCHEMBL28133754

O=C(c1ccccc1)c1cc(F)c(F)c(-c2ccccc2)c1-c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 1/20 0.44
ALDH1A1 P00352 4/20 0.44
ADORA1 P30542 1/20 0.43
AKR1C3 P42330 1/20 0.43
NR1H2 P55055 1/20 0.43
NR1H3 Q13133 1/20 0.43
CNR1 P21554 1/20 0.43
CNR2 P34972 1/20 0.43
HSD17B1 P14061 1/20 0.43
HSD17B2 P37059 1/20 0.43
ATM Q13315 2/20 0.42
CDC25B P30305 1/20 0.42
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
KDM4E B2RXH2 2/20 0.41
GAA P10253 2/20 0.41
CYP2C8 P10632 1/20 0.41
CYP2C9 P11712 1/20 0.41
MEN1 O00255 1/20 0.41
USP2 O75604 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28099665 0.82 NR1H2 (0.43) PDE4AALDH1A1ADORA1AKR1C3NR1H2
SCHEMBL4150417 0.79 RAB9A (0.52) ALDH1A1CNR1CNR2HSD17B1HSD17B2
SCHEMBL8769335 0.79 AKR1C3 (0.48) PDE4AALDH1A1AKR1C3HSD17B1HSD17B2
SCHEMBL10277177 0.78 MEN1 (0.50) PDE4AALDH1A1ADORA1AKR1C3CNR1
SCHEMBL29164143 0.77 ALDH1A1 (0.52) PDE4AALDH1A1ADORA1AKR1C3CNR1
SCHEMBL27449650 0.76 ALDH1A1 (0.54) PDE4AALDH1A1ADORA1AKR1C3ATM
SCHEMBL10647658 0.76 BCL2 (0.53) ALDH1A1AKR1C3HSD17B1HSD17B2ATM
SCHEMBL1505897 0.76 TTR (0.53) PDE4AALDH1A1ADORA1AKR1C3NR1H2
SCHEMBL10644840 0.75 HPGD (0.48) PDE4AALDH1A1AKR1C3ATMTDP1
SCHEMBL15793447 0.75 MAPT (0.50) ALDH1A1ADORA1AKR1C3ATMTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106459489-B Stabilizer compounds 索尔维特殊聚合物美国有限责任公司 2019-07-12 CN disclosed
CN-105745277-B Crosslinking polymer composition for gas separation membrane 弗吉尼亚理工大学知识产权公司 2019-05-03 CN disclosed
CN-106459489-A Stabilizer compounds 索尔维特殊聚合物美国有限责任公司 2017-02-22 CN disclosed