Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bitolterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bitolterol SCHEMBL29385409 | 1.00 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL28133 | 1.00 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL30929319 | 1.00 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL30777231 | 1.00 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL11286987 | 0.99 | ADRB2 (0.55) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL4371 | 0.95 | LMNA (0.50) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL4372 | 0.95 | LMNA (0.50) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| SCHEMBL20169505 | 0.92 | LMNA (0.46) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Hydrochloric Acid SCHEMBL11276480 | 0.92 | ADRB2 (0.48) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| SCHEMBL11277082 | 0.92 | LMNA (0.47) | LMNAHIF1AALDH1A1CYP3A4ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 11574 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-20250213647-A1 | CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE | UNIVERSITY OF SOUTH FLORIDA | 2025-07-03 | — | — | US | claimed |
| US-20250195624-A1 | USE OF SUPEROXIDE DISMUTASE FOR THE TREATMENT AND/OR PREVENTION OF ALLERGIC ASTHMA | Isocell S.A.S. (FR) | 2025-06-19 | — | — | US | claimed |
| US-12329759-B2 | Methods and compositions relating to lung function | TRUSTEES OF BOSTON UNIVERSITY (US) | 2025-06-17 | — | — | US | claimed |
| WO-2025092300-A1 | USE OF ADRENORECEPTOR AGONISTS IN PROMOTING HEMATOPOIETIC REGENERATION | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2025-05-08 | — | — | WO | claimed |
| US-20250057764-A1 | COMPOSITIONS, METHODS AND SYSTEMS FOR AEROSOL DRUG DELIVERY | ASTRAZENECA AB (SE) | 2025-02-20 | — | — | US | claimed |
| US-20250017878-A1 | USE OF NADOLOL TO TREAT CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY BLOCKAGE OF THE ARRESTIN-2 PATHWAY | CHRONIC AIRWAY THERAPEUTICS LTD (AU) | 2025-01-16 | — | — | US | claimed |
| EP-4482479-A1 | USE OF SUPEROXIDE DISMUTASE FOR THE TREATMENT AND/OR PREVENTION OF ALLERGIC ASTHMA | Isocell S.A.S. (FR) | 2025-01-01 | — | — | EP | claimed |
| US-20240398729-A1 | Methods and Compositions for the Treatment of Cytoplasmic Glycogen Storage Disorders | DUKE UNIVERSITY (US) | 2024-12-05 | — | — | US | claimed |
| EP-4452230-A1 | COMPOSITIONS, METHODS AND SYSTEMS FOR AEROSOL DRUG DELIVERY | Astrazeneca AB (SE) | 2024-10-30 | — | — | EP | claimed |
| WO-1990013327-A1 | DRY POWDER INHALATION DEVICE | RIKER LABORATORIES, INC. (US) | 1990-11-15 | — | — | WO | claimed |
| WO-1990013328-A1 | DRY POWDER INHALATION DEVICE | RIKER LABORATORIES, INC. (US) | 1990-11-15 | — | — | WO | claimed |
| US-4965065-A | ADMINISTERING NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH BETA ADRENERGIC AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1990-10-23 | — | — | US | claimed |
| EP-0209547-B1 | DRUG-CONTAINING CHLOROFLUOROCARBON AEROSOL PROPELLENT FORMULATIONS | RIKER LABORATORIES, INC. (US) | 1990-09-12 | — | — | EP | claimed |
| WO-1990006775-A1 | A NOVEL NONPHOSPHOLIPID LIPOSOME COMPOSITION FOR SUSTAINED RELEASE OF DRUGS | LIPOSOME TECHNOLOGY, INC. (US) | 1990-06-28 | — | — | WO | claimed |
| EP-0341559-A2 | Synergistic mixtures and their therapeutical use | BOEHRINGER INGELHEIM KG (DE) | 1989-11-15 | — | — | EP | claimed |
| EP-0190449-B1 | ADDITIVE-CONTAINING PAINTS | OECE Industrie Chimiche Spa (IT) | 1989-08-09 | — | — | EP | claimed |
| EP-0321918-A2 | Process for the enzymatic racemate cleavage of racemic alcohols with/in vinyl esters by transesterification | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-06-28 | — | — | EP | claimed |
| US-4778673-A | THERAPEUTIC OR PROPHYLACTIC ACTION TO PREVENT OR NEUTRALIZE IRRITATION OF RESPIRATORY TRACT MUCOSAE; TERPENES; ODORS | OECE INDUSTRIE CHIMICHE SPA (IT) | 1988-10-18 | — | — | US | claimed |
| EP-0248150-A1 | Gastroprotective process and compositions | Bristol-Myers Squibb Company (US) | 1987-12-09 | — | — | EP | claimed |