Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bitolterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bitolterol SCHEMBL28134 | 1.00 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL29385409 | 1.00 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL28133 | 1.00 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL30777231 | 1.00 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL11286987 | 0.99 | ADRB2 (0.55) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL4371 | 0.95 | LMNA (0.50) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL4372 | 0.95 | LMNA (0.50) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| SCHEMBL20169505 | 0.92 | LMNA (0.46) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Hydrochloric Acid SCHEMBL11276480 | 0.92 | ADRB2 (0.48) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| SCHEMBL11277082 | 0.92 | LMNA (0.47) | LMNAHIF1AALDH1A1CYP3A4ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4356912-A2 | HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS | Techfields Pharma Co., Ltd. (CN) | 2024-04-24 | — | — | EP | disclosed |