Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bitolterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bitolterol SCHEMBL4371 | 1.00 | LMNA (0.50) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| SCHEMBL11277082 | 0.96 | LMNA (0.47) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| SCHEMBL11287419 | 0.96 | LMNA (0.47) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| SCHEMBL11290655 | 0.96 | LMNA (0.47) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL30777231 | 0.95 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL30929319 | 0.95 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL29385409 | 0.95 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL28134 | 0.95 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL28133 | 0.95 | LMNA (0.54) | LMNAHIF1AALDH1A1CYP3A4ADRB2 | |
| Bitolterol SCHEMBL11286987 | 0.94 | ADRB2 (0.55) | LMNAHIF1AALDH1A1CYP3A4ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3853 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4547949-B1 | METHOD FOR PREHEATING AN AFTER-TREATMENT DEVICE | HORSE POWERTRAIN SOLUTIONS S L U (ES) | 2026-04-01 | — | — | EP | claimed |
| EP-4699655-A2 | COMPOUNDS | TMEM16A LIMITED (GB) | 2026-02-25 | — | — | EP | claimed |
| US-12377105-B2 | Compounds | TMEM16A LIMITED (GB) | 2025-08-05 | — | — | US | claimed |
| EP-4547949-A1 | METHOD FOR PREHEATING AN AFTER-TREATMENT DEVICE | Horse Powertrain Solutions, S.L.U. (ES) | 2025-05-07 | — | — | EP | claimed |
| US-20250134835-A1 | COMPOSITIONS AND METHODS FOR TREATING PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS (ALS) | CURASEN THERAPEUTICS, INC. | 2025-05-01 | — | — | US | claimed |
| CN-111683926-B | Compounds of formula (I) | 企业治疗学有限公司 | 2024-11-08 | — | — | CN | claimed |
| EP-3062572-B1 | VIRTUAL ANCHOR POINT-BASED WIRELESS LOCATING METHOD, DEVICE AND TERMINAL | ZTE CORP (CN) | 2024-10-23 | — | — | EP | claimed |
| US-12037336-B2 | Compounds with activity as inhibitors of the epithelial sodium channel (ENaC) | Enterprise Therapeutics Limited (GB) | 2024-07-16 | — | — | US | claimed |
| US-20240226084-A9 | HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS | TECHFIELDS PHARMA CO., LTD. (CN) | 2024-07-11 | — | — | US | claimed |
| US-20240131017-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS | TECHFIELDS PHARMA CO., LTD. (CN) | 2024-04-25 | — | — | US | claimed |
| WO-1995005805-A1 | PROCESS FOR CONDITIONING SUBSTANCES | ASTRA AKTIEBOLAG (SE) | 1995-03-02 | — | — | WO | claimed |
| EP-0602181-A1 | MEDICINAL AEROSOL FORMULATIONS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-06-22 | — | — | EP | claimed |
| WO-1993004671-A1 | MEDICINAL AEROSOL FORMULATIONS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1993-03-18 | — | — | WO | claimed |
| EP-0527940-A1 | DIRECT SPRAY-DRIED DRUG/LIPID POWDER COMPOSITION | LIPOSOME TECHNOLOGY, INC. (US) | 1993-02-24 | — | — | EP | claimed |
| WO-1991016882-A1 | DIRECT SPRAY-DRIED DRUG/LIPID POWDER COMPOSITION | LIPOSOME TECHNOLOGY, INC. (US) | 1991-11-14 | — | — | WO | claimed |
| EP-0209547-B1 | DRUG-CONTAINING CHLOROFLUOROCARBON AEROSOL PROPELLENT FORMULATIONS | RIKER LABORATORIES, INC. (US) | 1990-09-12 | — | — | EP | claimed |
| US-4895719-A | SUSPENSION, ENCAPSULATION, DRUG DELIVERY | LIPOSOME TECHNOLOGY, INC. (US) | 1990-01-23 | — | — | US | claimed |
| US-4814161-A | GLYCEROL PHOSPHATIDE | RIKER LABORATORIES, INC. (US) | 1989-03-21 | — | — | US | claimed |
| EP-0209547-A1 | DRUG-CONTAINING CHLOROFLUOROCARBON AEROSOL PROPELLENT FORMULATIONS. | RIKER LABORATORIES INC (US) | 1987-01-28 | — | — | EP | claimed |
| WO-1986004233-A1 | DRUG-CONTAINING CHLOROFLUOROCARBON AEROSOL PROPELLENT FORMULATIONS | RIKER LABORATORIES, INC. (US) | 1986-07-31 | — | — | WO | claimed |