Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL120092 | 0.85 | IDO1 (0.46) | IDO1TSHR | |
| SCHEMBL5733912 | 0.85 | IDO1 (0.46) | IDO1TSHR | |
| SCHEMBL5487052 | 0.85 | IDO1 (0.46) | IDO1TSHR | |
| SCHEMBL11029571 | 0.83 | IDO1 (0.44) | IDO1TSHR | |
| SCHEMBL31139277 | 0.80 | IDO1 (0.40) | IDO1TSHR | |
| SCHEMBL13226845 | 0.79 | PTGS2 (0.37) | IDO1LMNAPTGS2 | |
| SCHEMBL4197444 | 0.76 | NPC1 (0.50) | IDO1TRPV1SKP2CYP3A4PTGS2 | |
| SCHEMBL9243315 | 0.74 | PTGS2 (0.56) | TRPV1LMNACYP3A4PTGS2HPGD | |
| SCHEMBL2924850 | 0.74 | ACHE (0.36) | IDO1 | |
| Ethyne SCHEMBL28900275 | 0.73 | NPC1 (0.47) | IDO1TRPV1SKP2CYP3A4PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106928247-A | Spiral shell oxindole compounds and its purposes as therapeutic agent | 泽农医药公司 | 2017-07-07 | — | — | CN | disclosed |
| CN-103664973-B | Spiro-oxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-19 | — | — | CN | disclosed |