SCHEMBL28136339

SCHEMBL28136339

S=C=NC(Cc1cccs1)c1cccs1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.41
MIF P14174 1/20 0.37
TAAR1 Q96RJ0 1/20 0.34
ADRA2A P08913 3/20 0.34
ADRA2B P18089 3/20 0.34
ADRA2C P18825 3/20 0.34
CTSC P53634 4/20 0.34
LMNA P02545 4/20 0.34
RAB9A P51151 1/20 0.34
ALDH1A1 P00352 1/20 0.34
GAA P10253 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
KEAP1 Q14145 1/20 0.33
MEN1 O00255 1/20 0.32
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.32
HTT P42858 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8099297 0.77 MIF (0.44) MIFRAB9AKMT2A
SCHEMBL4966557 0.71 CYP2C19 (0.57) CYP2C19TAAR1ADRA2AADRA2BADRA2C
SCHEMBL28135571 0.70 MIF (0.50) MIFRAB9AALDH1A1GAASMN1; SMN2
SCHEMBL324034 0.68 CYP2C19 (0.48) CYP2C19TAAR1ADRA2AADRA2BADRA2C
SCHEMBL9022952 0.68 CYP2C19 (0.48) CYP2C19TAAR1ADRA2AADRA2BADRA2C
SCHEMBL8092464 0.67 CES2 (0.31) MIFCES2CES1KEAP1
SCHEMBL10390855 0.67
SCHEMBL3512988 0.66
SCHEMBL9379212 0.66 CYP2C19 (0.46) CYP2C19TAAR1ADRA2AADRA2BADRA2C
SCHEMBL28195666 0.65 ALDH1A1 (0.36) CYP2C19MIFCTSCLMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106518838-A Synthesis of 2-thienylethyl isothiocyanate 山东高洁环保科技有限公司 2017-03-22 CN claimed