Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.37 |
| ▸ | TUBB | P07437 | 2/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11196372 | 0.84 | RELA (0.45) | LMNARELAMAOBMAPTSMN1; SMN2 | |
| SCHEMBL7101868 | 0.80 | CYP2C19 (0.45) | CYP2C19HDAC3EGFRNPC1L3MBTL1 | |
| SCHEMBL7101867 | 0.80 | CYP2C19 (0.45) | CYP2C19HDAC3EGFRNPC1L3MBTL1 | |
| SCHEMBL2785211 | 0.78 | EGFR (0.45) | CYP2C19HDAC3EGFRNPC1L3MBTL1 | |
| (Z)-1,2-Diphenylethene SCHEMBL28882092 | 0.77 | RELA (0.54) | HDAC3EGFRLMNATDP1RELA | |
| SCHEMBL2787746 | 0.77 | EGFR (0.48) | CYP2C19HDAC3EGFRNPC1L3MBTL1 | |
| SCHEMBL6858892 | 0.77 | EGFR (0.48) | CYP2C19HDAC3EGFRNPC1L3MBTL1 | |
| SCHEMBL10998351 | 0.76 | CYP2C19 (0.41) | CYP2C19HDAC3EGFRNPC1L3MBTL1 | |
| SCHEMBL23406262 | 0.75 | EGFR (0.50) | CYP2C19HDAC3EGFRNPC1L3MBTL1 | |
| SCHEMBL28096624 | 0.75 | EGFR (0.47) | CYP2C19HDAC3EGFRNPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2192108-B1 | Novel dihydronaphthalene compound and use thereof | UNIV TOKYO SCI EDUC FOUND (JP) | 2013-03-27 | — | — | EP | disclosed |
| US-8183235-B2 | Dihydronaphthalene compound and use thereof | TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) | 2012-05-22 | — | — | US | disclosed |
| US-20100249400-A1 | NOVEL DIHYDRONAPHTHALENE COMPOUND AND USE THEREOF | TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) | 2010-09-30 | — | — | US | disclosed |
| EP-2192108-A1 | NOVEL DIHYDRONAPHTHALENE COMPOUND AND USE THEREOF | Tokyo University Of Science Educational Foundation Administrative Organization (JP) | 2010-06-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249400-A1 | NOVEL DIHYDRONAPHTHALENE COMPOUND AND USE THEREOF | PSME1, NDUFB1, NDUFB10 | CYP2C19 1757/4885HDAC3 702/4885EGFR 2000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.