Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 5/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.41 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2812157 | 0.88 | SMN1; SMN2 (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2814452 | 0.88 | SMN1; SMN2 (0.41) | EHMT2SIGMAR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2808272 | 0.87 | ACHE (0.46) | EHMT2CACNA1GCACNA1HCACNA1ISIGMAR1 | |
| SCHEMBL2814240 | 0.86 | ACHE (0.39) | EHMT2SIGMAR1MEN1KMT2AACHE | |
| SCHEMBL2812219 | 0.85 | MAPT (0.42) | EHMT2SMN1; SMN2MEN1KMT2AACHE | |
| SCHEMBL2812911 | 0.85 | MAPT (0.38) | EHMT2SIGMAR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2810354 | 0.85 | MAPT (0.39) | EHMT2SIGMAR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2816710 | 0.85 | EHMT2 (0.43) | EHMT2SIGMAR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2809346 | 0.84 | SIGMAR1 (0.38) | CACNA1GCACNA1HCACNA1ISIGMAR1MEN1 | |
| SCHEMBL2814133 | 0.84 | ACHE (0.43) | EHMT2CACNA1GCACNA1HCACNA1ISIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343983-B2 | Substituted pyrazolo-pyrimidine compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | DPYD, TYMP, TP53 | HDAC3 1889/4885HDAC4 2007/4885HDAC1 1518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.