Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | GDA | Q9Y2T3 | 3/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | MGMT | P16455 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27461919 | 0.83 | GDA (0.58) | DPP4PNPGDAPDPK1MGMT | |
| SCHEMBL27796380 | 0.77 | PI4KA (0.52) | PDPK1CYP1A2HSD17B10CDK2NEK2 | |
| SCHEMBL1749123 | 0.75 | PI4KA (0.53) | PDPK1CYP1A2HSD17B10CDK2NEK2 | |
| SCHEMBL31599206 | 0.73 | HDAC1 (0.40) | GDAPDPK1MGMTNEK2SRC | |
| SCHEMBL30751337 | 0.72 | PDE4A (0.57) | PNPMGMTCYP1A2CYP2C19HSD17B10 | |
| SCHEMBL1721311 | 0.70 | ALDH1A1 (0.55) | DPP4PNPGDAMGMTCDK2 | |
| SCHEMBL9639791 | 0.69 | GAA (0.40) | DPP4PNPGDAPDPK1MGMT | |
| SCHEMBL29509029 | 0.69 | GDA (0.58) | DPP4PNPGDAPDPK1MGMT | |
| SCHEMBL1684049 | 0.69 | GDA (0.58) | DPP4PNPGDAPDPK1MGMT | |
| SCHEMBL31360592 | 0.69 | CYP1A2 (0.37) | DPP4PNPGDAPDPK1MGMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108992446-A | With TOR kinase inhibitor for treating cancer | 西格诺药品有限公司 | 2018-12-14 | — | — | CN | disclosed |
| CN-104271159-B | The method that non-small cell lung cancer is treated using the therapeutic alliance of TOR kinase inhibitors | 西格诺药品有限公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-107157990-A | Utilize TOR kinase inhibitor for treating cancers | 西格诺药品有限公司 | 2017-09-15 | — | — | CN | disclosed |
| CN-107137402-A | With TOR kinase inhibitor for treating cancers | 西格诺药品有限公司 | 2017-09-08 | — | — | CN | disclosed |
| CN-104302295-B | Treatment of cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2017-06-20 | — | — | CN | disclosed |
| CN-103998036-B | Treatment of cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2017-05-31 | — | — | CN | disclosed |