Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28148240 | 0.99 | ALOX5AP (0.50) | ALOX5APPIK3CDPIK3CATDO2METAP2 | |
| SCHEMBL28286116 | 0.88 | CYP1A2 (0.55) | METAP2CYP1A2CYP3A4ALDH1A1TSHR | |
| SCHEMBL28871485 | 0.88 | CYP2C19 (0.49) | PIK3CDPIK3CATDO2METAP2CYP1A2 | |
| SCHEMBL18069431 | 0.75 | PIK3CA (0.52) | PIK3CDPIK3CATDO2KDM4EMEN1 | |
| SCHEMBL24377491 | 0.74 | ALDH1A1 (0.55) | ALOX5APPIK3CACYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL8870802 | 0.73 | MAP4K4 (0.54) | PIK3CDPIK3CAMAPTEGFR | |
| SCHEMBL27389897 | 0.71 | IP6K1 (0.53) | PIK3CDPIK3CAKDM4EEGFR | |
| SCHEMBL28018836 | 0.71 | PIK3CD (0.48) | PIK3CDPIK3CATDO2ALDH1A1EGFR | |
| SCHEMBL24196910 | 0.70 | ALOX5AP (0.50) | ALOX5APMETAP2CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL28296832 | 0.70 | PIK3CD (0.50) | PIK3CDPIK3CATDO2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106588871-B | A kind of 2- substituted pyridinyl quinazolinone analog derivative, its preparation method and use | 贵州大学 | 2019-04-16 | — | — | CN | disclosed |
| CN-106588871-A | 2-substituted pyridyl quinazolinone derivative and synthesis method and application thereof | 贵州大学 | 2017-04-26 | — | — | CN | disclosed |