Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.47 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 4/20 | 0.44 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL163742 | 0.78 | NAMPT (0.49) | ABCC9ABCC8KCNJ11KCNJ8KAT6A | |
| SCHEMBL22954096 | 0.78 | KAT6A (0.53) | ABCC9ABCC8KCNJ11KCNJ8KAT6A | |
| SCHEMBL1146161 | 0.75 | HSD11B1 (0.59) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9778961 | 0.74 | PTGES2 (0.52) | ABCC9ABCC8KCNJ11KCNJ8KAT6A | |
| SCHEMBL4072013 | 0.72 | KAT6A (0.45) | KAT6APTGES2SLC22A12NAMPTSLC40A1 | |
| SCHEMBL28811119 | 0.72 | SLC40A1 (0.66) | NAMPTSLC40A1HTT | |
| SCHEMBL3163460 | 0.71 | HSD11B1 (0.47) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL30468568 | 0.71 | ALDH1A1 (0.62) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8514629 | 0.71 | ALDH1A1 (0.62) | HSD11B1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6958215 | 0.71 | POLB (0.50) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103384668-B | compounds and compositions for inhibition of NAMPT | 福马TM有限责任公司 | 2017-05-31 | — | — | CN | disclosed |