Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27836650 | 0.84 | LMNA (0.52) | LMNAL3MBTL1KDRMETAP2METAP1 | |
| SCHEMBL28399316 | 0.82 | LMNA (0.50) | LMNAL3MBTL1KDRMETAP2METAP1 | |
| SCHEMBL28397400 | 0.82 | LMNA (0.50) | LMNAL3MBTL1KDRMETAP2METAP1 | |
| SCHEMBL22072300 | 0.81 | LMNA (0.49) | LMNAL3MBTL1KDRMETAP2METAP1 | |
| SCHEMBL7522659 | 0.79 | LMNA (0.47) | LMNAL3MBTL1KDRMETAP2METAP1 | |
| SCHEMBL3096310 | 0.79 | KDM4E (0.47) | LMNAKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL9001643 | 0.77 | KMT2A (0.53) | LMNAKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL10992802 | 0.76 | L3MBTL1 (0.54) | LMNAL3MBTL1METAP2METAP1HDAC6 | |
| SCHEMBL14507079 | 0.76 | KMT2A (0.58) | LMNAKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL14960087 | 0.75 | TNKS (0.65) | L3MBTL1KMT2AKDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106938985-B | 5-site alkenylated 8-acylaminoquinoline compound and one-pot preparation method thereof | 湖南大学 | 2020-05-05 | — | — | CN | disclosed |
| CN-106938985-A | A kind of 5 amide groups quinolines of alkenyl 8 and its one-pot preparation thereof | 湖南大学 | 2017-07-11 | — | — | CN | disclosed |