SCHEMBL28154689

SCHEMBL28154689

CCOCN1CCOCC1.F[B-](F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.36
MAPK1 P28482 3/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
KDM4E B2RXH2 5/20 0.35
GAA P10253 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
ALDH1A1 P00352 5/20 0.35
HTT P42858 2/20 0.35
CYP1A2 P05177 1/20 0.34
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34
HTR2A P28223 1/20 0.34
SCN1A P35498 1/20 0.34
HTR2B P41595 1/20 0.34
KCNH2 Q12809 1/20 0.34
SCN2A Q99250 1/20 0.34
SIGMAR1 Q99720 1/20 0.34
SCN3A Q9NY46 1/20 0.34
HRH3 Q9Y5N1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3305232 0.92 TSHR (0.41) TSHRMAPK1SMN1; SMN2KDM4EGAA
SCHEMBL347618 0.78 USP2 (0.44) TSHRSMN1; SMN2KDM4EGAAMEN1
SCHEMBL28151463 0.76 KDM4E (0.41) TSHRMAPK1SMN1; SMN2KDM4EGAA
SCHEMBL3304899 0.75 ALDH1A1 (0.43) TSHRMAPK1SMN1; SMN2KDM4EGAA
SCHEMBL4906908 0.75 ALDH1A1 (0.30) ALDH1A1
SCHEMBL347311 0.73 USP2 (0.41) TSHRSMN1; SMN2KDM4EGAAMEN1
SCHEMBL28208697 0.72 ALDH1A1 (0.45) TSHRMAPK1SMN1; SMN2KDM4EMEN1
SCHEMBL3305208 0.72 ALDH1A1 (0.53) TSHRMAPK1SMN1; SMN2MEN1KMT2A
Hydrogen Sulfide SCHEMBL17888866 0.72 USP2 (0.39) TSHRSMN1; SMN2KDM4EGAAMEN1
SCHEMBL474810 0.71 ALDH1A1 (0.51) TSHRMAPK1SMN1; SMN2KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106753300-A A kind of double effect compound type hydrate inhibitor and preparation method thereof 中国科学院广州能源研究所 2017-05-31 CN disclosed