Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LOX | P28300 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16246275 | 0.80 | NPC1 (0.48) | MAPTMEN1KMT2ATP53NPC1 | |
| SCHEMBL28156720 | 0.80 | MAPT (0.64) | MAPTMEN1KMT2ATP53NPC1 | |
| SCHEMBL28156717 | 0.79 | MEN1 (0.50) | MAPTMEN1KMT2ATP53TDP1 | |
| SCHEMBL28157321 | 0.77 | TP53 (0.44) | MAPTMEN1KMT2ATP53TDP1 | |
| SCHEMBL28846379 | 0.77 | HPGD (0.52) | MAPTMEN1KMT2ATP53TDP1 | |
| SCHEMBL28157305 | 0.77 | MEN1 (0.48) | MAPTMEN1KMT2ATP53TDP1 | |
| SCHEMBL28156718 | 0.77 | KAT6A (0.50) | MAPTMEN1KMT2ATDP1NPC1 | |
| SCHEMBL28846257 | 0.76 | MEN1 (0.47) | MEN1KMT2ATP53TDP1NPC1 | |
| SCHEMBL28157366 | 0.75 | MAPT (0.41) | MAPTMEN1KMT2ATP53TDP1 | |
| SCHEMBL28156742 | 0.75 | LMNA (0.52) | MAPTMEN1KMT2ATP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105531268-B | Noval chemical compound and its pharmaceutical composition for treating cystic fibrosis | 加拉佩格斯股份有限公司 | 2017-09-12 | — | — | CN | disclosed |