Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28156749 | 0.81 | CFTR (0.47) | ALDH1A1HTT | |
| SCHEMBL16338033 | 0.80 | CFTR (0.56) | MEN1KMT2APOLBRAB9ATNF | |
| SCHEMBL28156807 | 0.78 | MEN1 (0.53) | MEN1KMT2APOLBRAB9ATNF | |
| SCHEMBL28157292 | 0.74 | L3MBTL1 (0.44) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL28156798 | 0.74 | ALDH1A1 (0.33) | KMT2ARAB9AHDAC6ALDH1A1HTT | |
| SCHEMBL28846483 | 0.71 | RAB9A (0.43) | MEN1KMT2APOLBRAB9ATNF | |
| SCHEMBL31045268 | 0.69 | SMN1; SMN2 (0.57) | MEN1KMT2AALDH1A1APLNRHTT | |
| SCHEMBL28156802 | 0.67 | HDAC4 (0.54) | MEN1KMT2APOLBRAB9ATNF | |
| SCHEMBL25347015 | 0.66 | ALDH1A1 (0.48) | MEN1KMT2AACLYALDH1A1TAS2R14 | |
| SCHEMBL28156726 | 0.65 | CFTR (0.50) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105531268-B | Noval chemical compound and its pharmaceutical composition for treating cystic fibrosis | 加拉佩格斯股份有限公司 | 2017-09-12 | — | — | CN | disclosed |