Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | XDH | P47989 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16173478 | 0.87 | RORC (0.44) | KMOTSHRALDH1A1RORCIRAK4 | |
| SCHEMBL2811357 | 0.84 | CYP1A2 (0.44) | KMOKDM4EL3MBTL1TSHRALDH1A1 | |
| SCHEMBL2812232 | 0.81 | P2RX7 (0.46) | KMOMCL1ALDH1A1RORCIRAK4 | |
| SCHEMBL11894355 | 0.81 | KDM4E (0.67) | KMOKDM4EL3MBTL1XDHALOX15 | |
| SCHEMBL29375401 | 0.81 | KDM4E (0.66) | KMOKDM4EL3MBTL1ALOX15TSHR | |
| SCHEMBL1759891 | 0.81 | KDM4E (0.66) | KMOKDM4EL3MBTL1ALOX15TSHR | |
| Hydrochloric Acid SCHEMBL7225758 | 0.79 | KDM4E (0.64) | KMOKDM4EL3MBTL1ALOX15TSHR | |
| SCHEMBL11894473 | 0.79 | KDM4E (0.54) | KMOKDM4EL3MBTL1XDHALOX15 | |
| SCHEMBL16741093 | 0.74 | KDM4E (0.49) | KMOKDM4EL3MBTL1XDHPTGER1 | |
| SCHEMBL2306249 | 0.73 | KMO (0.49) | KMOKDM4EL3MBTL1ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103403004-A | Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMA | 2013-11-20 | — | — | CN | disclosed |
| WO-2010117662-A1 | MODULATORS OF S1P AND METHODS OF MAKING AND USING | EXELIXIS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| US-20100249071-A1 | Modulators of S1P and Methods of Making And Using | EXELIXIS, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249071-A1 | Modulators of S1P and Methods of Making And Using | EXELIXIS, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249071-A1 | Modulators of S1P and Methods of Making And Using | EXELIXIS, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249071-A1 | Modulators of S1P and Methods of Making And Using | S1PR5, S1PR1, S1PR2 | KMO 1138/4885KDM4E 1216/4885L3MBTL1 3241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.