Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17321298 | 0.84 | MEN1 (0.36) | EPHX2MEN1KMT2ANOTUMALDH1A1 | |
| SCHEMBL15956120 | 0.72 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL17288793 | 0.71 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL23189106 | 0.70 | MEN1 (0.38) | MEN1KMT2AALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL19980443 | 0.70 | KMT2A (0.38) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL17288792 | 0.70 | ALDH1A1 (0.36) | MEN1KMT2AALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL15956383 | 0.67 | MAPT (0.45) | ALDH1A1TSHRSMN1; SMN2NPC1 | |
| SCHEMBL28225146 | 0.67 | NOTUM (0.68) | MEN1KMT2ANOTUMALDH1A1RAB9A | |
| SCHEMBL17321300 | 0.66 | TSHR (0.41) | ALDH1A1TSHR | |
| SCHEMBL4779771 | 0.66 | NOTUM (0.51) | MEN1KMT2ANOTUMALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108774214-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-105121432-B | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-08-03 | — | — | CN | disclosed |
| CN-106928203-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2017-07-07 | — | — | CN | disclosed |