Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725344 | 0.85 | NOTUM (0.36) | NOTUMMEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL4725676 | 0.83 | HRH1 (0.35) | NOTUMMEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL4777782 | 0.81 | MEN1 (0.35) | NOTUMMEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL14291874 | 0.81 | CYP2D6 (0.45) | NOTUMADRA1AMEN1KMT2ACHRM2 | |
| SCHEMBL4725202 | 0.79 | SMN1; SMN2 (0.42) | ADRA1AMEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL4727513 | 0.78 | CHRM3 (0.44) | NOTUMMEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL11826155 | 0.76 | RORC (0.42) | MEN1KMT2ACHRM2CHRM4CHRM5 | |
| SCHEMBL3770253 | 0.73 | NOTUM (0.42) | NOTUMMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL1848863 | 0.71 | NOTUM (0.53) | NOTUMMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL411505 | 0.71 | NOTUM (0.43) | NOTUML3MBTL1CHEK1AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023157-A1 | NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS M3-RECEPTOR MODULATORS | ARGENTA DISCOVERY LIMITED (GB) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008023157-A1 | NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS M3-RECEPTOR MODULATORS | ARGENTA DISCOVERY LIMITED (GB) | 2008-02-28 | — | — | WO | disclosed |