Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.44 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | VCP | P55072 | 2/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2808272 | 0.89 | ACHE (0.46) | ACHEBACE1TLR7SIGMAR1KMT2A | |
| SCHEMBL2811744 | 0.88 | ACHE (0.38) | ACHEBACE1TLR7GRIN2BKMT2A | |
| SCHEMBL2814452 | 0.87 | SMN1; SMN2 (0.41) | ACHEBACE1TLR7SIGMAR1KMT2A | |
| SCHEMBL2814133 | 0.86 | ACHE (0.43) | ACHEBACE1TLR7SIGMAR1KMT2A | |
| SCHEMBL2809610 | 0.85 | ACHE (0.44) | ACHEBACE1SIGMAR1KMT2AMEN1 | |
| SCHEMBL2814240 | 0.85 | ACHE (0.39) | ACHEBACE1TLR7SIGMAR1KMT2A | |
| SCHEMBL2809346 | 0.85 | SIGMAR1 (0.38) | ACHEBACE1TLR7SIGMAR1KMT2A | |
| SCHEMBL2811710 | 0.84 | TUBB4A (0.43) | ACHEBACE1TLR7KMT2AMEN1 | |
| SCHEMBL2812911 | 0.84 | MAPT (0.38) | ACHEBACE1TLR7SIGMAR1KMT2A | |
| SCHEMBL2812219 | 0.84 | MAPT (0.42) | ACHEBACE1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343983-B2 | Substituted pyrazolo-pyrimidine compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | DPYD, TYMP, TP53 | ACHE 4402/4885BACE1 3588/4885VCP 3284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.