Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 13/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15890444 | 1.00 | MAPT (0.55) | MAPTTHRBLMNABCHEALDH1A1 | |
| SCHEMBL602195 | 0.93 | BCHE (0.49) | MAPTTHRBLMNABCHE | |
| SCHEMBL14679919 | 0.86 | BCHE (0.54) | MAPTTHRBLMNABCHE | |
| SCHEMBL2816476 | 0.86 | MAPT (0.53) | MAPTTHRBLMNABCHEALDH1A1 | |
| SCHEMBL11357547 | 0.86 | MAPT (0.53) | MAPTTHRBLMNABCHEALDH1A1 | |
| SCHEMBL2890384 | 0.86 | MAPT (0.53) | MAPTTHRBLMNABCHEALDH1A1 | |
| SCHEMBL2816475 | 0.86 | MAPT (0.53) | MAPTTHRBLMNABCHEALDH1A1 | |
| SCHEMBL2890392 | 0.86 | MAPT (0.53) | MAPTTHRBLMNABCHEALDH1A1 | |
| SCHEMBL603118 | 0.84 | BCHE (0.46) | MAPTTHRBLMNABCHEALDH1A1 | |
| SCHEMBL25065678 | 0.84 | MAPT (0.56) | MAPTTHRBLMNABCHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3220905-B1 | COMBINATIONS OF PROSTAGLANDINS AND NITRIC OXIDE DONORS | NICOX SA (FR) | 2019-10-09 | — | — | EP | claimed |
| US-20170354634-A1 | COMBINATIONS OF PROSTAGLANDINS AND NITRIC OXIDE DONORS | NICOX S.A. (FR) | 2017-12-14 | — | — | US | claimed |
| EP-3220905-A1 | COMBINATIONS OF PROSTAGLANDINS AND NITRIC OXIDE DONORS | Nicox S.A. (FR) | 2017-09-27 | — | — | EP | claimed |
| WO-2016079142-A1 | COMBINATIONS OF PROSTAGLANDINS AND NITRIC OXIDE DONORS | NICOX S.A. (FR) | 2016-05-26 | — | — | WO | claimed |
| US-10610509-B2 | Combinations of prostaglandins and nitric oxide donors | NICOX S.A. (FR) | 2020-04-07 | — | — | US | disclosed |
| EP-3220905-B1 | COMBINATIONS OF PROSTAGLANDINS AND NITRIC OXIDE DONORS | NICOX SA (FR) | 2019-10-09 | — | — | EP | disclosed |
| US-20170354634-A1 | COMBINATIONS OF PROSTAGLANDINS AND NITRIC OXIDE DONORS | NICOX S.A. (FR) | 2017-12-14 | — | — | US | disclosed |
| EP-3220905-A1 | COMBINATIONS OF PROSTAGLANDINS AND NITRIC OXIDE DONORS | Nicox S.A. (FR) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016079142-A1 | COMBINATIONS OF PROSTAGLANDINS AND NITRIC OXIDE DONORS | NICOX S.A. (FR) | 2016-05-26 | — | — | WO | disclosed |
| EP-2238143-B1 | NITRIC OXIDE DONOR COMPOUNDS | NICOX SA (FR) | 2012-08-15 | — | — | EP | disclosed |
| US-20100249189-A1 | NITRIC OXIDE DONOR COMPOUNDS | NICOX S.A. (FR) | 2010-09-30 | — | — | US | disclosed |
| WO-2009150007-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | NICOX S.A. (FR) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170354634-A1 | COMBINATIONS OF PROSTAGLANDINS AND NITRIC OXIDE DONORS | PTGIS, PTGIR, PTGS1 | MAPT 4432/4885THRB 3197/4885LMNA 4124/4885 |
| US-20100249189-A1 | NITRIC OXIDE DONOR COMPOUNDS | NOS3, NOS1, NOS2 | MAPT 4444/4885THRB 2627/4885LMNA 2520/4885 |
| US-10610509-B2 | Combinations of prostaglandins and nitric oxide donors | PTGIS, PTGIR, PTGS1 | MAPT 4432/4885THRB 3197/4885LMNA 4124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.