Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1564325 | 0.98 | MET (0.49) | METPAX8LIMK2TAAR1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL28165652 | 0.96 | MET (0.47) | METPAX8LIMK2TAAR1L3MBTL1 | |
| SCHEMBL4050760 | 0.81 | MET (0.35) | METPAX8LIMK2 | |
| SCHEMBL27836688 | 0.81 | HTT (0.51) | L3MBTL1 | |
| SCHEMBL1564294 | 0.81 | HTR1A (0.49) | L3MBTL1DRD2 | |
| SCHEMBL25430673 | 0.77 | TAAR1 (0.43) | METPAX8TAAR1HTR2ACALM1 | |
| SCHEMBL20682499 | 0.77 | NOS3 (0.41) | L3MBTL1 | |
| SCHEMBL31568984 | 0.77 | HTT (0.54) | L3MBTL1DRD4 | |
| SCHEMBL29501702 | 0.76 | MET (0.50) | METPAX8LIMK2HTR2ACALM1 | |
| SCHEMBL2232473 | 0.76 | MET (0.50) | METPAX8LIMK2TAAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107075302-A | The film formation composition of the silicon containing crosslinking reactivity | 日产化学工业株式会社 | 2017-08-18 | — | — | CN | disclosed |