Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2819735 | 0.94 | ALDH1A1 (0.46) | GSK3AGSK3BALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2815188 | 0.88 | CA1 (0.42) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL2814448 | 0.86 | LMNA (0.56) | ALDH1A1MAPTSMN1; SMN2RAB9ATSHR | |
| SCHEMBL2819102 | 0.85 | GRIN2B (0.41) | ALDH1A1SMN1; SMN2ADRA1DADRA1AADRA1B | |
| SCHEMBL540215 | 0.85 | CASP3 (0.47) | GSK3AGSK3BALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2816972 | 0.84 | GRM5 (0.41) | ALDH1A1MAPTSMN1; SMN2RAB9AADRA1A | |
| SCHEMBL2817078 | 0.81 | MEN1 (0.56) | ALDH1A1MAPTSMN1; SMN2RAB9AATM | |
| SCHEMBL2816647 | 0.81 | LMNA (0.49) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL2820930 | 0.80 | CYP1A2 (0.46) | ALDH1A1CYP1A2MAPTSMN1; SMN2RAB9A | |
| SCHEMBL2818190 | 0.79 | HPGD (0.56) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906928-B2 | Substituted pyrazolo-pyrrolo-pyridine-dione compounds | ARQULE, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906928-B2 | Substituted pyrazolo-pyrrolo-pyridine-dione compounds | ARQULE, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906928-B2 | Substituted pyrazolo-pyrrolo-pyridine-dione compounds | ARQULE, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20100249120-A1 | SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249120-A1 | SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249120-A1 | SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249120-A1 | SUBSTITUTED PYRAZOLO-PYRROLO-PYRIDINE-DIONE COMPOUNDS | MKI67, TP53, PDK1 | GSK3A 1743/4885GSK3B 1463/4885ALDH1A1 1053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.