Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.63 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | MGLL | Q99685 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28513784 | 0.86 | MGLL (0.61) | HSD11B1ALDH1A1MEN1KMT2AMGLL | |
| SCHEMBL28504433 | 0.84 | POLB (0.66) | HSD11B1ALDH1A1KMT2AMGLLPOLB | |
| SCHEMBL1809345 | 0.83 | ADRB2 (0.71) | HSD11B1PARP10KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL16333619 | 0.83 | HSD11B1 (0.74) | HSD11B1KDM4EALDH1A1KMT2AMGLL | |
| SCHEMBL28422447 | 0.82 | HTT (0.47) | HSD11B1PARP10ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL28171808 | 0.82 | EPHX2 (0.54) | HSD11B1ALDH1A1EPHX2 | |
| SCHEMBL4399941 | 0.82 | HSD11B1 (0.69) | HSD11B1PARP10KDM4EALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4617268 | 0.81 | HSD11B1 (0.67) | HSD11B1PARP10KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL30967272 | 0.80 | HSD11B1 (0.71) | HSD11B1KDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL6985975 | 0.79 | CA12 (0.71) | HSD11B1KDM4EALDH1A1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107226808-B | Tankyrase inhibitors | 北京四环制药有限公司 | 2021-01-01 | — | — | CN | disclosed |
| CN-107226808-A | Tankyrase inhibitor | 山东轩竹医药科技有限公司 | 2017-10-03 | — | — | CN | disclosed |