Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | UBE2M | P61081 | 1/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2817332 | 0.94 | CHRM4 (0.53) | CHRM4POLBLMNAMAPTHTT | |
| SCHEMBL2818101 | 0.86 | CHRM4 (0.52) | CHRM4POLBLMNAMAPTHTT | |
| SCHEMBL3638063 | 0.86 | CHRM4 (0.52) | CHRM4POLBLMNAMAPTHTT | |
| SCHEMBL2817840 | 0.82 | POLB (0.44) | CHRM4POLBLMNAMAPTHTT | |
| SCHEMBL2819008 | 0.79 | CHRM4 (0.48) | CHRM4DRD2DRD3 | |
| SCHEMBL2818348 | 0.79 | CHRM4 (0.44) | CHRM4POLBLMNAMAPTHTT | |
| SCHEMBL2818426 | 0.78 | CHRM4 (0.49) | CHRM4POLBLMNAMAPTHTT | |
| SCHEMBL2817087 | 0.78 | CHRM4 (0.49) | CHRM4POLBLMNAMAPTHTT | |
| SCHEMBL3979720 | 0.77 | NPBWR1 (0.42) | POLBLMNAMAPTHTTNPBWR1 | |
| SCHEMBL2820467 | 0.76 | LMNA (0.49) | CHRM4POLBLMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155672-B1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-10-27 | — | — | EP | claimed |