Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563581 | 0.84 | BRD4 (0.42) | BRD4CREBBPKMT2AMEN1ALOX15 | |
| SCHEMBL30885716 | 0.76 | KMT2A (0.50) | KMT2AMEN1HSD17B10MAPK1CA1 | |
| SCHEMBL7207965 | 0.73 | ALOX15 (0.41) | BRD4CREBBPKMT2AMEN1ALOX15 | |
| SCHEMBL27827131 | 0.70 | BRD4 (0.42) | BRD4CREBBPALOX15HSD17B10MAPK1 | |
| SCHEMBL28413210 | 0.70 | MAPK1 (0.47) | BRD4CREBBPKMT2AMEN1HSD17B10 | |
| SCHEMBL11923135 | 0.69 | BRD4 (0.48) | BRD4CREBBPALOX15HSD17B10MAPK1 | |
| SCHEMBL19673900 | 0.69 | ALOX15 (0.41) | BRD4CREBBPKMT2AMEN1ALOX15 | |
| SCHEMBL27738677 | 0.69 | ALDH1A1 (0.41) | BRD4KMT2AMEN1HSD17B10MAPK1 | |
| SCHEMBL1033548 | 0.68 | KMT2A (0.66) | KMT2AMEN1HSD17B10MAPK1L3MBTL1 | |
| Indoline SCHEMBL27276532 | 0.68 | PDPK1 (0.46) | KMT2AMEN1ALOX15HSD17B10CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207467-A | 2, 4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG | 癌症研究科技有限公司 | 2017-09-26 | — | — | CN | disclosed |