SCHEMBL28178997

SCHEMBL28178997

O=C(O)c1ccc(Br)c([N+](=O)[O-])c1I

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
TDP1 Q9NUW8 2/20 0.40
CYP3A4 P08684 1/20 0.40
ALOX15 P16050 1/20 0.40
GPR35 Q9HC97 2/20 0.40
CYP1A2 P05177 2/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
TSHR P16473 1/20 0.37
PKM P14618 1/20 0.36
DTYMK P23919 1/20 0.36
MAPT P10636 1/20 0.34
ERN1 O75460 1/20 0.34
CDK2 P24941 1/20 0.33
AKR1C2 P52895 1/20 0.33
AKR1C1 Q04828 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28318439 0.81 TDP1 (0.41) ALDH1A1TDP1CYP3A4ALOX15GPR35
SCHEMBL28036070 0.80 ALDH1A1 (0.43) ALDH1A1TDP1CYP3A4ALOX15GPR35
SCHEMBL8068839 0.79 TSHR (0.51) ALDH1A1TDP1CYP3A4ALOX15GPR35
SCHEMBL25294147 0.79 ALDH1A1 (0.40) ALDH1A1TDP1CYP3A4ALOX15GPR35
SCHEMBL431501 0.79 ALDH1A1 (0.46) ALDH1A1TDP1CYP3A4ALOX15TSHR
SCHEMBL28451753 0.79 ALDH1A1 (0.37) ALDH1A1TDP1CYP3A4GPR35CYP2D6
SCHEMBL15566605 0.79 GPR35 (0.51) ALDH1A1TDP1CYP3A4ALOX15GPR35
SCHEMBL9013992 0.77 TSHR (0.49) ALDH1A1TDP1CYP3A4ALOX15GPR35
SCHEMBL30252887 0.77 TDP1 (0.54) ALDH1A1TDP1CYP3A4ALOX15CYP1A2
SCHEMBL1161724 0.77 TSHR (0.51) ALDH1A1TDP1CYP3A4ALOX15GPR35

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107501023-A The method that one kind prepares halo (miscellaneous) aromatic hydrocarbons 辽宁大学 2017-12-22 CN disclosed