Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 7/20 | 0.37 |
| ▸ | WNT3A | P56704 | 7/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28182835 | 0.91 | CTNNB1 (0.38) | CTNNB1WNT3AMAP2K1KAT6AMTNR1A | |
| SCHEMBL28182768 | 0.76 | CTNNB1 (0.49) | CTNNB1WNT3AHDAC3HDAC4HDAC1 | |
| SCHEMBL25165984 | 0.74 | PKM (0.43) | CTNNB1WNT3AMAP2K1KAT6AMTNR1A | |
| SCHEMBL25166570 | 0.72 | ALDH1A1 (0.48) | CTNNB1WNT3AMAP2K1KAT6AMTNR1A | |
| SCHEMBL31108055 | 0.72 | ALDH1A1 (0.48) | CTNNB1WNT3AMAP2K1KAT6AMTNR1A | |
| SCHEMBL11451235 | 0.68 | MTNR1A (0.40) | CTNNB1WNT3AMAP2K1KAT6AMTNR1A | |
| SCHEMBL28182761 | 0.68 | CTNNB1 (0.41) | CTNNB1WNT3A | |
| SCHEMBL29588474 | 0.67 | KDM4E (0.51) | MAP2K1KAT6AMTNR1AMTNR1BPARP1 | |
| SCHEMBL24469644 | 0.67 | KDM4E (0.51) | MAP2K1KAT6AMTNR1AMTNR1BPARP1 | |
| SCHEMBL28182766 | 0.67 | CTNNB1 (0.50) | CTNNB1WNT3AHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107383024-B | The class compound of fused tricyclic containing imidazoles and its application | 广州必贝特医药技术有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-107383024-A | The class compound of fused tricyclic containing imidazoles and its application | 广州必贝特医药技术有限公司 | 2017-11-24 | — | — | CN | disclosed |