Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166123 | 0.83 | HPGD (0.47) | PARP1MEN1KMT2ACASP7USP2 | |
| SCHEMBL173290 | 0.83 | ANPEP (0.43) | PARP1MEN1KMT2ACASP7USP2 | |
| SCHEMBL14562917 | 0.81 | GABRA1 (0.46) | THRBCYP1A2CYP3A4BLMANPEP | |
| SCHEMBL2820121 | 0.80 | HPGD (0.45) | PARP1MEN1KMT2ACASP7USP2 | |
| SCHEMBL6468586 | 0.80 | PARP1 (0.50) | PARP1MEN1KMT2ACASP7USP2 | |
| SCHEMBL2820310 | 0.80 | SMN1; SMN2 (0.44) | MEN1KMT2APOLBMAPTCYP3A4 | |
| SCHEMBL5326248 | 0.77 | PARP1 (0.39) | PARP1MEN1KMT2ACASP7USP2 | |
| SCHEMBL22525287 | 0.77 | CASP3 (0.52) | PARP1CASP7ANPEPMAOAALDH1A1 | |
| SCHEMBL29372946 | 0.74 | PARP1 (0.53) | PARP1MEN1KMT2ACASP7USP2 | |
| SCHEMBL221618 | 0.74 | PARP1 (0.53) | PARP1MEN1KMT2ACASP7USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008154353-A1 | THALIDOMIDE ANALOGS FOR TREATING VASCULAR ABNORMALITIES | CHARLESSON, LLC (US) | 2008-12-18 | — | — | WO | claimed |
| US-20080306134-A1 | THALIDOMIDE ANALOGS FOR TREATING VASCULAR ABNORMALITIES | CHARLESSON, LLC | 2008-12-11 | — | — | US | claimed |
| CN-101904841-B | Phthalide imide analogue and application thereof in preparing medicine for treating diabetic macular edema | DANYANG CHEN | 2012-09-19 | — | — | CN | disclosed |
| CN-102503884-A | Synthesis method of phenylphthalimide analog | DANYANG CHEN | 2012-06-20 | — | — | CN | disclosed |
| US-20100247659-A1 | PHENYLPHTHALIMIDE ANALOGS FOR TREATING DIABETIC MACULAR EDEMA | CHARLESSON, LLC (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100247659-A1 | PHENYLPHTHALIMIDE ANALOGS FOR TREATING DIABETIC MACULAR EDEMA | CHARLESSON, LLC (US) | 2010-09-30 | — | — | US | disclosed |
| WO-2008154353-A1 | THALIDOMIDE ANALOGS FOR TREATING VASCULAR ABNORMALITIES | CHARLESSON, LLC (US) | 2008-12-18 | — | — | WO | disclosed |
| US-20080306134-A1 | THALIDOMIDE ANALOGS FOR TREATING VASCULAR ABNORMALITIES | CHARLESSON, LLC | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100247659-A1 | PHENYLPHTHALIMIDE ANALOGS FOR TREATING DIABETIC MACULAR EDEMA | SLC2A8, VEGFA, SLC2A1 | PARP1 1892/4885MEN1 3601/4885KMT2A 3840/4885 |
| US-20080306134-A1 | THALIDOMIDE ANALOGS FOR TREATING VASCULAR ABNORMALITIES | VEGFA, FLT1, VCAM1 | PARP1 4318/4885MEN1 1218/4885KMT2A 2668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.