Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.64 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | PEPD | P12955 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.49 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.49 |
| ▸ | ALB | P02768 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172516 | 1.00 | KIF11 (0.64) | KIF11NR1H4MAPTGAAGFER | |
| SCHEMBL2815572 | 0.86 | NR1H4 (0.54) | KIF11NR1H4MAPTGAAPTGS2 | |
| SCHEMBL4109704 | 0.86 | NR1H4 (0.54) | KIF11NR1H4MAPTGAAGFER | |
| SCHEMBL2170471 | 0.86 | NR1H4 (0.54) | KIF11NR1H4MAPTGAAPTGS2 | |
| SCHEMBL7479983 | 0.85 | NR1H4 (0.59) | KIF11NR1H4MAPTGAAPTGS2 | |
| Ibuprofen SCHEMBL11678091 | 0.83 | MAPT (0.70) | KIF11MAPTGAAPEPDPTGS2 | |
| SCHEMBL9823526 | 0.83 | POLB (0.58) | NR1H4MAPTGAAPTGS2ALDH1A1 | |
| SCHEMBL5533028 | 0.82 | KIF11 (0.89) | KIF11MAPTGAAGFERGLA | |
| SCHEMBL261230 | 0.82 | KIF11 (0.60) | KIF11MAPTGAAGFERGLA | |
| SCHEMBL2170717 | 0.82 | KIF11 (0.60) | KIF11MAPTGAAGFERGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249198-A1 | (R)-4-(HETEROARYL) PHENYLETHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE S.P.A (IT) | 2010-09-30 | — | — | US | disclosed |
| EP-2201006-A1 | (R)-4-(HETEROARYL) PHENYLETHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dompé S.p.a. (IT) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009050258-A1 | (R)-4-(HETEROARYL) PHENYLETHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dompé S.p.A. (IT) | 2009-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249198-A1 | (R)-4-(HETEROARYL) PHENYLETHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | C3AR1, C5AR2, C5AR1 | KIF11 3713/4885NR1H4 55/4885MAPT 4486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.