Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.89 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.58 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.58 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.58 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.58 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | PEPD | P12955 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5427819 | 0.94 | KIF11 (1.00) | KIF11NPC1GLAGRIN2DGRIN3B | |
| SCHEMBL12894680 | 0.84 | KIF11 (0.66) | KIF11NPC1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7663512 | 0.84 | KIF11 (0.66) | KIF11NPC1GLAGRIN2DGRIN3B | |
| SCHEMBL19707622 | 0.83 | RAB9A (0.76) | KIF11NPC1CA12CA1CA2 | |
| SCHEMBL2172516 | 0.82 | KIF11 (0.64) | KIF11NPC1GLAPEPDMEN1 | |
| SCHEMBL2818448 | 0.82 | KIF11 (0.64) | KIF11NPC1GLAPEPDMEN1 | |
| SCHEMBL5062623 | 0.82 | PEPD (0.80) | KIF11NPC1GLACA1CA2 | |
| SCHEMBL13881478 | 0.81 | KIF11 (0.62) | KIF11NPC1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL30140931 | 0.81 | KIF11 (0.62) | KIF11NPC1GLACA12CA1 | |
| SCHEMBL1027400 | 0.81 | KIF11 (0.61) | KIF11NPC1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240262801-A1 | COMPOUNDS HAVING 5-(2-FLUORO-6-HYDROXYPHENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE AS INHIBITORS OF PROTEIN KINASE PHOSPHATASE ENZYMES | MONDEGO BIO, LDA. (PT) | 2024-08-08 | — | — | US | claimed |
| CN-1146320-C | Enhancement of seed yield of soybeans by substituted benzoyl urea | 尤尼罗亚尔化学公司 | 2004-04-21 | — | — | CN | claimed |
| CN-1406110-A | Enhancement of seed/fruit/nut yield from flowering plants | UNIROYAL CHEM CO INC (US) | 2003-03-26 | — | — | CN | claimed |
| CN-1272040-A | Enhancement of seed yield of soybeans by substituted benzoyl urea | UNIROYAL CHEM CO INC (US) | 2000-11-01 | — | — | CN | claimed |
| CN-1221316-A | Benzoylurea insecticides on gene-modified Bt cotton | UNIROYAL CHEM CO INC (US) | 1999-06-30 | — | — | CN | claimed |
| US-5696110-A | ANTIULCER AGENTS | MERCK, SHARP & DOHME, LTD. (GB) | 1997-12-09 | — | — | US | claimed |
| CN-1063279-A | The method of synthetic herbicide isoproturon | SHANDONG TEACHERS UNIVERSITY (CN) | 1992-08-05 | — | — | CN | claimed |
| US-20240262801-A1 | COMPOUNDS HAVING 5-(2-FLUORO-6-HYDROXYPHENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE AS INHIBITORS OF PROTEIN KINASE PHOSPHATASE ENZYMES | MONDEGO BIO, LDA. (PT) | 2024-08-08 | — | — | US | disclosed |
| CN-114213286-B | Synthetic method of urea derivative | 湖北文理学院 | 2022-12-30 | — | — | CN | disclosed |
| WO-2022133034-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| CN-114213286-A | Synthetic method of urea derivative | 湖北文理学院 | 2022-03-22 | — | — | CN | disclosed |
| US-20210371413-A1 | POLYCYCLIC AMIDES AS CYTOTOXIC AGENTS | Pheon Therapeutics Ltd. (GB) | 2021-12-02 | — | — | US | disclosed |
| US-20210107923-A1 | CYTOTOXIC AGENTS | PHEON THERAPEUTICS LTD (GB) | 2021-04-15 | — | — | US | disclosed |
| WO-1997045017-A1 | BENZOYLUREA INSECTICIDES ON GENE-MODIFIED Bt COTTON | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1997-12-04 | — | — | WO | disclosed |
| CN-1063279-A | The method of synthetic herbicide isoproturon | SHANDONG TEACHERS UNIVERSITY (CN) | 1992-08-05 | — | — | CN | disclosed |
| CN-1063279-A | The method of synthetic herbicide isoproturon | SHANDONG TEACHERS UNIVERSITY (CN) | 1992-08-05 | — | — | CN | disclosed |
| EP-0182166-B1 | PROCESS FOR PREPARING PHENYLISOPROPYLUREA COMPOUNDS | AMERICAN CYANAMID COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |
| US-4814499-A | CONDENSATION OF ANILINE, UREA, AMINE | RHONE-POULENC AGROCHIMIE (FR) | 1989-03-21 | — | — | US | disclosed |
| EP-0182166-A2 | Process for preparing phenylisopropylurea compounds | AMERICAN CYANAMID COMPANY (US) | 1986-05-28 | — | — | EP | disclosed |
| US-4578513-A | Process for preparing phenylisopropylurea compounds | AMERICAN CYANAMID COMPANY (US) | 1986-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210371413-A1 | POLYCYCLIC AMIDES AS CYTOTOXIC AGENTS | PBRM1, NFATC1, ACIN1 | KIF11 1841/4885NPC1 2212/4885GLA 3104/4885 |
| US-20240262801-A1 | COMPOUNDS HAVING 5-(2-FLUORO-6-HYDROXYPHENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE AS INHIBITORS OF PROTEIN KINASE PHOSPHATASE ENZYMES | PPM1A, TH, PPM1G | KIF11 3848/4885NPC1 2925/4885GLA 1587/4885 |
| US-20210107923-A1 | CYTOTOXIC AGENTS | MKI67, TP53, NFATC1 | KIF11 232/4885NPC1 911/4885GLA 1380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.