Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2815572 | 1.00 | NR1H4 (0.54) | NR1H4ALDH1A1TSHRTP53TYR | |
| SCHEMBL2172516 | 0.86 | KIF11 (0.64) | NR1H4ALDH1A1TSHRPTGS2KIF11 | |
| SCHEMBL2818448 | 0.86 | KIF11 (0.64) | NR1H4ALDH1A1TSHRPTGS2KIF11 | |
| SCHEMBL262073 | 0.83 | ALDH1A1 (0.47) | ALDH1A1TSHRTP53TYRTAS2R38 | |
| SCHEMBL2171946 | 0.83 | ALDH1A1 (0.47) | ALDH1A1TSHRTP53TYRTAS2R38 | |
| SCHEMBL2170844 | 0.83 | ALDH1A1 (0.47) | ALDH1A1TSHRTP53TYRTAS2R38 | |
| SCHEMBL4109704 | 0.83 | NR1H4 (0.54) | NR1H4ALDH1A1TSHRPTGS2KIF11 | |
| SCHEMBL7479983 | 0.82 | NR1H4 (0.59) | NR1H4ALDH1A1TSHRPTGS2KIF11 | |
| SCHEMBL11576346 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TSHRTP53TYRTAS2R38 | |
| SCHEMBL9823526 | 0.80 | POLB (0.58) | NR1H4ALDH1A1TSHRHSD17B10PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346841-B1 | 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPÉ S P A (IT) | 2015-01-14 | — | — | EP | disclosed |
| US-8624036-B2 | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them | DOMPE S.P.A. (IT) | 2014-01-07 | — | — | US | disclosed |
| US-20110207785-A1 | 2-Aryl-Propionic Acids and Derivatives and Pharmaceutical Compositions Containing Them | DOMPE S.P.A. (IT) | 2011-08-25 | — | — | US | disclosed |
| EP-2346841-A2 | 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dompe S.p.A. (IT) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010031835-A2 | 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' S.P.A. (IT) | 2010-03-25 | — | — | WO | disclosed |
| EP-2166006-A1 | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them | Dompe' S.P.A. (IT) | 2010-03-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207785-A1 | 2-Aryl-Propionic Acids and Derivatives and Pharmaceutical Compositions Containing Them | CXCR3, F2RL1, FPR2 | NR1H4 227/4885ALDH1A1 1221/4885TSHR 2635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.