Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.52 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.52 |
| ▸ | ALB | P02768 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | RARB | P10826 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.52 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823526 | 0.86 | POLB (0.58) | NR1H4PTGS2PTGS1AKR1C3LMNA | |
| SCHEMBL2818448 | 0.85 | KIF11 (0.64) | NR1H4PTGS2PTGS1AKR1C3LMNA | |
| SCHEMBL2172516 | 0.85 | KIF11 (0.64) | NR1H4PTGS2PTGS1AKR1C3LMNA | |
| SCHEMBL5727353 | 0.85 | NR1H4 (0.45) | NR1H4PTGS2LMNATSHRMAPT | |
| SCHEMBL28905039 | 0.83 | KIF11 (0.47) | NR1H4AKR1C3LMNAESR1TSHR | |
| SCHEMBL1027400 | 0.83 | KIF11 (0.61) | LMNANFKB1MAPTMEN1KMT2A | |
| SCHEMBL6136348 | 0.83 | CASP3 (0.63) | NR1H4PTGS2LMNATSHRMAPT | |
| SCHEMBL10033271 | 0.83 | SMN1; SMN2 (0.56) | NR1H4PTGS2PTGS1AKR1C3LMNA | |
| SCHEMBL16258135 | 0.83 | NR1H4 (0.55) | NR1H4PTGS2PTGS1AKR1C3LMNA | |
| SCHEMBL59197 | 0.82 | PTGS2 (0.74) | PTGS2PTGS1AKR1C3LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229010-A1 | NOVEL DIARYLAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |