Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL8031251 | 0.89 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3ADRB2HTR1A | |
| Lactic Acid SCHEMBL8196434 | 0.88 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3ADRB2HTR1A | |
| SCHEMBL540787 | 0.88 | EPHX1 (0.41) | EPHX1SLC6A2SLC6A4SLC6A3ADRB2 | |
| Octadecanoic Acid Amide SCHEMBL28187430 | 0.88 | SOAT1 (0.35) | EPHX1IRAK4 | |
| Lactic Acid SCHEMBL27651674 | 0.87 | GPR84 (0.35) | EPHX1 | |
| Lactic Acid SCHEMBL4337807 | 0.85 | SLC6A2 (0.35) | SLC6A2SLC6A4SLC6A3ADRB2HTR1A | |
| Lactic Acid SCHEMBL4170980 | 0.80 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3ADRB2HTR1A | |
| Octadecanoic Acid Amide SCHEMBL28237217 | 0.79 | SOAT1 (0.41) | EPHX1 | |
| Acetamide SCHEMBL2691464 | 0.78 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3ADRB2HTR1A | |
| Lactic Acid SCHEMBL427896 | 0.77 | FAAH (0.41) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108143709-A | Promote the method and medical composition of the 5th type phosphodiesterase inhibitors percutaneous absorbtion | 天津普茂企业孵化器有限公司 | 2018-06-12 | — | — | CN | disclosed |
| CN-107489015-A | A kind of underwear mellowing method | 王露 | 2017-12-19 | — | — | CN | disclosed |
| CN-103998043-B | Method and pharmaceutical composition for promoting percutaneous absorption of phosphodiesterase type V inhibitor | 群泰生物科技股份有限公司 | 2016-09-21 | — | — | CN | disclosed |