Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 10/20 | 0.43 |
| ▸ | RAB9A | P51151 | 10/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28324685 | 0.94 | SIGMAR1 (0.53) | SIGMAR1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6258947 | 0.89 | SIGMAR1 (0.65) | SIGMAR1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL28561721 | 0.85 | SIGMAR1 (0.56) | SIGMAR1NPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL28192173 | 0.85 | SIGMAR1 (0.56) | SIGMAR1NPC1RAB9ASMN1; SMN2MAOB | |
| SCHEMBL28192152 | 0.84 | SIGMAR1 (0.58) | SIGMAR1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6040419 | 0.82 | SIGMAR1 (0.54) | SIGMAR1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL28324632 | 0.79 | SIGMAR1 (0.53) | SIGMAR1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL10620662 | 0.78 | SIGMAR1 (0.67) | SIGMAR1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL28192141 | 0.77 | SIGMAR1 (0.54) | SIGMAR1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL28854194 | 0.76 | SIGMAR1 (0.52) | SIGMAR1NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107417628-A | Diaryl quianzolinones, its preparation method and its medical usage and the pharmaceutical composition comprising such compound | 中国人民解放军军事医学科学院毒物药物研究所 | 2017-12-01 | — | — | CN | claimed |
| CN-107417628-A | Diaryl quianzolinones, its preparation method and its medical usage and the pharmaceutical composition comprising such compound | 中国人民解放军军事医学科学院毒物药物研究所 | 2017-12-01 | — | — | CN | disclosed |