Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | CPB1 | P15086 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28193038 | 0.90 | PNMT (0.39) | ACECPB1CPB2ITGB3ITGA2B | |
| Lysine SCHEMBL28455173 | 0.89 | ITGB3 (0.50) | ACEITGB3ITGA2BCTSLTYR | |
| SCHEMBL27718876 | 0.89 | CTSK (0.47) | CTSKCAPN1CAPN2CTSLTYR | |
| SCHEMBL22804081 | 0.89 | CTSK (0.47) | CTSKCAPN1CAPN2CTSLTYR | |
| SCHEMBL30460474 | 0.89 | CTSK (0.47) | CTSKCAPN1CAPN2CTSLTYR | |
| SCHEMBL2234378 | 0.89 | CTSK (0.47) | CTSKCAPN1CAPN2CTSLTYR | |
| SCHEMBL31005798 | 0.89 | CTSK (0.47) | CTSKCAPN1CAPN2CTSLTYR | |
| Arginine SCHEMBL29034304 | 0.88 | NPY4R (0.43) | CAPN1CAPN2TYRTGM2 | |
| SCHEMBL31190266 | 0.88 | ACE (0.51) | ACECPB1CPB2ITGB3ITGA2B | |
| SCHEMBL5613893 | 0.88 | ACE (0.51) | ACECPB1CPB2ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107529532-A | R9 antibacterial polypeptides and preparation method thereof | 兰州瑞贝药物研发有限公司 | 2018-01-02 | — | — | CN | disclosed |