Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 3/20 | 0.44 |
| ▸ | ECE1 | P42892 | 7/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28099063 | 0.87 | KMT2A (0.65) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL3495873 | 0.82 | KDM4E (0.73) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL3498464 | 0.82 | KDM4E (0.73) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL28844063 | 0.82 | MEN1 (0.48) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL28130698 | 0.81 | KMT2A (0.45) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL28144336 | 0.81 | RXFP1 (0.41) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL28003348 | 0.79 | KDM4E (0.73) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL6146838 | 0.78 | KMT2A (0.80) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL1487570 | 0.78 | KMT2A (0.80) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL21199671 | 0.78 | KMT2A (0.60) | MEN1KMT2AKDM4ELMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107596379-A | A kind of responsive intelligent periodontal medicine controlled releasing hydrogel materials of MMP 8 and application thereof | 武汉大学 | 2018-01-19 | — | — | CN | disclosed |