Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | IL23R | Q5VWK5 | 6/20 | 0.40 |
| ▸ | PTH1R | Q03431 | 5/20 | 0.39 |
| ▸ | MAGI3 | Q5TCQ9 | 1/20 | 0.39 |
| ▸ | GLP1R | P43220 | 2/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | GIPR | P48546 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL27746464 | 0.94 | RXFP1 (0.42) | RXFP1IL23RPTH1RMAGI3GLP1R | |
| Dl-Tryptophan SCHEMBL28880639 | 0.86 | KDM4E (0.45) | RXFP1PRMT1IL23RPTH1RKDM4E | |
| Dl-Tryptophan SCHEMBL28130698 | 0.84 | KMT2A (0.45) | PRMT1KDM4EMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28844063 | 0.83 | MEN1 (0.48) | PRMT1KDM4EMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28079286 | 0.82 | KDM4E (0.43) | PRMT1PTH1RMAGI3GLP1RKDM4E | |
| Dl-Tryptophan SCHEMBL29151523 | 0.82 | KDM4E (0.54) | PRMT1KDM4EMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL16762301 | 0.81 | KDM4E (0.50) | PRMT1IL23RKDM4EMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28196606 | 0.81 | MEN1 (0.49) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL29025197 | 0.81 | KMT2A (0.54) | PRMT1KDM4EMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28066306 | 0.81 | KDM4E (0.54) | PRMT1KDM4EMEN1LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106977589-A | A kind of citrus fruit fly antibacterial peptide and its preparation method and application | 四川科劲生物科技有限公司 | 2017-07-25 | — | — | CN | disclosed |