Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 4/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 2/20 | 0.40 |
| ▸ | MC5R | P33032 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28131402 | 0.85 | KMT2A (0.58) | KMT2AMEN1KDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL28861116 | 0.85 | KMT2A (0.58) | KMT2AMEN1KDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL28130701 | 0.85 | KDM4E (0.63) | KMT2AMEN1KDM4ELMNAMPO | |
| Tryptophan SCHEMBL28144336 | 0.84 | RXFP1 (0.41) | KMT2AMEN1KDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL29151523 | 0.83 | KDM4E (0.54) | KMT2AMEN1KDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL28099063 | 0.83 | KMT2A (0.65) | KMT2AMEN1KDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL28250969 | 0.82 | KDM4E (0.54) | KMT2AMEN1KDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL29176788 | 0.82 | KDM4E (0.58) | KMT2AMEN1KDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL27137424 | 0.82 | KDM4E (0.58) | KMT2AMEN1KDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL27660745 | 0.81 | KMT2A (0.63) | KMT2AMEN1KDM4ELMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106478771-A | A kind of synthetic method of amino acid neural tetrapeptide | 李世军 | 2017-03-08 | — | — | CN | claimed |
| CN-106478771-A | A kind of synthetic method of amino acid neural tetrapeptide | 李世军 | 2017-03-08 | — | — | CN | disclosed |