Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.44 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.44 |
| ▸ | GHSR | Q92847 | 4/20 | 0.42 |
| ▸ | MC4R | P32245 | 2/20 | 0.41 |
| ▸ | MC5R | P33032 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | IL1RN | P18510 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28099063 | 0.85 | KMT2A (0.65) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL9220819 | 0.85 | KDM4E (0.65) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL28144336 | 0.83 | RXFP1 (0.41) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL7763177 | 0.82 | KDM4E (0.60) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL28196606 | 0.82 | MEN1 (0.49) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL2638019 | 0.81 | KDM4E (0.59) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL28130698 | 0.81 | KMT2A (0.45) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL1860250 | 0.81 | KDM4E (0.73) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL27703709 | 0.81 | KDM4E (0.73) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL8860168 | 0.80 | KMT2A (0.57) | MEN1KMT2AKDM4ELMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106977589-A | A kind of citrus fruit fly antibacterial peptide and its preparation method and application | 四川科劲生物科技有限公司 | 2017-07-25 | — | — | CN | disclosed |