SCHEMBL28197899

SCHEMBL28197899

COc1ccc(-n2c(N)cc(C)c2-c2ccc(C)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.48
HTT P42858 1/20 0.48
CUL4A Q13619 1/20 0.48
RAB9A P51151 4/20 0.45
ALDH1A1 P00352 2/20 0.45
NPSR1 Q6W5P4 1/20 0.45
ACHE P22303 1/20 0.44
LMNA P02545 1/20 0.43
NPY5R Q15761 1/20 0.41
NPC1 O15118 3/20 0.40
EGFR P00533 1/20 0.40
KDR P35968 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CNR1 P21554 1/20 0.40
OXTR P30559 1/20 0.40
KMT2A Q03164 1/20 0.40
GLA P06280 1/20 0.39
ALOX5 P09917 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6283390 0.73 ALDH1A1 (0.47) HTTRAB9AALDH1A1LMNASMN1; SMN2
SCHEMBL15694897 0.72 HPGD (0.52) HPGDHTTCUL4ARAB9AALDH1A1
SCHEMBL17052682 0.72 HPGD (0.52) HPGDHTTCUL4ARAB9AALDH1A1
SCHEMBL28197186 0.71 ALDH1A1 (0.51) HPGDHTTCUL4ARAB9AALDH1A1
Hydrazine SCHEMBL27971879 0.69 ACHE (0.75) RAB9AALDH1A1NPSR1ACHENPC1
SCHEMBL295716 0.69 ACHE (0.83) RAB9ANPSR1ACHENPC1EGFR
SCHEMBL3676881 0.69 ACHE (0.83) RAB9ANPSR1ACHENPC1EGFR
SCHEMBL12714843 0.69 ACHE (0.83) RAB9ANPSR1ACHENPC1EGFR
SCHEMBL12980511 0.69 HPGD (0.52) HPGDHTTCUL4ARAB9AALDH1A1
SCHEMBL445315 0.67 OXTR (0.51) HPGDHTTRAB9AALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107573273-A A kind of preparation method of three substitution, 3 cyanopyrrole analog derivatives 浙江大学 2018-01-12 CN claimed