⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14831272 | 0.75 | — | — | |
| SCHEMBL28263204 | 0.70 | SIGMAR1 (0.42) | — | |
| SCHEMBL28198731 | 0.69 | SRD5A1 (0.35) | — | |
| SCHEMBL11095529 | 0.67 | DRD4 (0.31) | — | |
| SCHEMBL4674255 | 0.62 | — | — | |
| SCHEMBL4698269 | 0.62 | — | — | |
| SCHEMBL12486426 | 0.60 | HTR2A (0.33) | — | |
| SCHEMBL23435612 | 0.59 | HTR2A (0.33) | — | |
| SCHEMBL3023146 | 0.58 | HTR3A (0.38) | — | |
| SCHEMBL2303039 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250270220-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2025-08-28 | — | — | US | disclosed |
| US-12304915-B2 | SOS1 inhibitors | Mirati Therapeutics, Inc. (US) | 2025-05-20 | — | — | US | disclosed |
| US-11702418-B2 | SOS1 inhibitors | Mirati Therapeutics, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20230137886-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. | 2023-05-04 | — | — | US | disclosed |
| CN-107540659-A | Tetrahydroisoquinolicompounds compounds, its preparation method, medical composition and its use | 四川科伦博泰生物医药股份有限公司 | 2018-01-05 | — | — | CN | disclosed |