Itaconate

Itaconate

SCHEMBL28200318

C=C(C)C(=O)OC(=O)CCC(=O)OC(=O)C(=C)C.C=C(CC(=O)O)C(=O)O

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.46
HSD17B10 Q99714 1/20 0.46
ALDH1A1 P00352 2/20 0.39
TSHR P16473 5/20 0.32
THRB P10828 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10352154 0.85 ALDH1A1 (0.44) ALOX15HSD17B10ALDH1A1TSHRTHRB
Itaconate SCHEMBL8660291 0.83 ALOX15 (0.49) ALOX15HSD17B10ALDH1A1
SCHEMBL1252855 0.83 EGLN1 (0.43) HSD17B10ALDH1A1TSHRTHRB
SCHEMBL895687 0.82 ALDH1A1 (0.48) HSD17B10ALDH1A1TSHRTHRB
Itaconate SCHEMBL28181571 0.81 THRB (0.46) ALOX15HSD17B10ALDH1A1TSHRTHRB
Itaconate SCHEMBL15419775 0.81 ALDH1A1 (0.62) ALOX15HSD17B10ALDH1A1TSHRTHRB
Itaconate SCHEMBL29289404 0.81 ALDH1A1 (0.47) ALOX15HSD17B10ALDH1A1TSHRTHRB
Itaconate SCHEMBL28072799 0.81 ALOX15 (0.48) ALOX15HSD17B10ALDH1A1TSHRTHRB
SCHEMBL28514124 0.81 ALDH1A1 (0.48) ALOX15HSD17B10ALDH1A1TSHRTHRB
SCHEMBL28684494 0.80 ALDH1A1 (0.46) HSD17B10ALDH1A1TSHRTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107703658-A The manufacture method of substrate 东京应化工业株式会社 2018-02-16 CN disclosed