Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28201169 | 0.83 | NAALAD2 (0.35) | NAALAD2HPGDHTTLMNAKDM4E | |
| SCHEMBL28108413 | 0.83 | L3MBTL1 (0.41) | HPGDKMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL28201172 | 0.80 | MME (0.38) | NAALAD2KMT2AMEN1HTTLMNA | |
| SCHEMBL18912366 | 0.77 | ACACB (0.52) | KMT2ASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL28108424 | 0.74 | FPR2 (0.41) | HPGDKDM4EHCAR3ALDH1A1 | |
| SCHEMBL28108427 | 0.71 | NAALAD2 (0.37) | NAALAD2HPGDKMT2AMEN1HTT | |
| SCHEMBL8527616 | 0.69 | HPGD (0.69) | HPGDKMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL25060915 | 0.67 | — | — | |
| SCHEMBL20341491 | 0.66 | KDM4E (0.51) | KMT2AHTTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL20341502 | 0.66 | KDM4E (0.51) | KMT2AHTTSMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104520277-B | Enkephalinase inhibitors | 施万生物制药研发IP有限责任公司 | 2018-01-19 | — | — | CN | disclosed |
| CN-105992763-A | Neprilysin inhibitors | 施万生物制药研发IP有限责任公司 | 2016-10-05 | — | — | CN | disclosed |
| CN-105960398-A | 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors | 施万生物制药研发IP有限责任公司 | 2016-09-21 | — | — | CN | disclosed |