Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1,2-Dichlorobenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | FEN1 | P39748 | 2/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,2-Dichlorobenzene SCHEMBL8356206 | 0.85 | TSHR (0.67) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL27871244 | 0.85 | TSHR (0.67) | TSHRLMNAALDH1A1CES2CES1 | |
| Oxalic Acid SCHEMBL28200216 | 0.84 | TSHR (0.58) | TSHRLMNAALDH1A1CES2CES1 | |
| Chlorobenzene SCHEMBL28280446 | 0.83 | TSHR (0.61) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL27323908 | 0.82 | TSHR (0.83) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL8528441 | 0.80 | TSHR (0.59) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL27754908 | 0.80 | TSHR (0.59) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL27273002 | 0.79 | TSHR (0.67) | TSHRLMNAALDH1A1CES2CES1 | |
| 2-Chlorophenol SCHEMBL28048093 | 0.79 | ALDH1A1 (0.75) | TSHRLMNAALDH1A1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL27321264 | 0.78 | TSHR (0.77) | TSHRLMNAALDH1A1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107663161-A | A kind of continuous stream synthesis technique of phenylhydrazine salt and substituted benzene hydrazonium salt | 上海惠和化德生物科技有限公司 | 2018-02-06 | — | — | CN | disclosed |