Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1,2-Dichlorobenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,2-Dichlorobenzene SCHEMBL28643400 | 0.95 | LMNA (0.56) | LMNATSHRHPGDHSP90AA1HSD17B10 | |
| Nitric Acid SCHEMBL28200191 | 0.86 | TSHR (0.44) | LMNATSHRHSP90AA1ALDH1A1CA5A | |
| Nitric Acid SCHEMBL28649276 | 0.84 | TSHR (0.65) | LMNATSHRHPGDHSP90AA1ALDH1A1 | |
| Nitric Acid SCHEMBL9805652 | 0.80 | TSHR (0.48) | TSHRHPGDHSP90AA1ALDH1A1CA5A | |
| Nitric Acid SCHEMBL27828035 | 0.79 | HSD17B10 (0.48) | LMNATSHRHPGDHSP90AA1HSD17B10 | |
| 1,2-Dichlorobenzene SCHEMBL28182721 | 0.79 | LMNA (0.56) | LMNATSHRHPGDHSP90AA1HSD17B10 | |
| Nitric Acid SCHEMBL20984897 | 0.79 | LMNA (0.49) | LMNAHPGDALDH1A1KMT2AMAPK1 | |
| 2,6-Dichlorophenol SCHEMBL10638279 | 0.78 | GPR35 (0.48) | LMNATSHRHSP90AA1ALDH1A1CA5A | |
| Nitric Acid SCHEMBL11001827 | 0.78 | LMNA (0.56) | LMNAHPGDCES2CES1ALDH1A1 | |
| 1,2-Dichlorobenzene SCHEMBL27323908 | 0.78 | TSHR (0.83) | LMNATSHRCES2CES1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107663161-A | A kind of continuous stream synthesis technique of phenylhydrazine salt and substituted benzene hydrazonium salt | 上海惠和化德生物科技有限公司 | 2018-02-06 | — | — | CN | disclosed |