Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL28200191 | 0.95 | TSHR (0.44) | TSHRHSP90AA1TDP1ALDH1A1ERCC5 | |
| Nitric Acid SCHEMBL28514807 | 0.85 | TDP1 (0.47) | TSHRHSP90AA1TDP1ALDH1A1ERCC5 | |
| 1,2-Dichlorobenzene SCHEMBL28643400 | 0.84 | LMNA (0.56) | TSHRHSP90AA1TDP1ALDH1A1KMT2A | |
| 2,6-Dichlorophenol SCHEMBL10638279 | 0.83 | GPR35 (0.48) | TSHRHSP90AA1TDP1ALDH1A1MEN1 | |
| Nitric Acid SCHEMBL20984111 | 0.80 | MEN1 (0.47) | TDP1ALDH1A1MEN1KMT2AHPGD | |
| 1,2-Dichlorobenzene SCHEMBL28200720 | 0.80 | LMNA (0.50) | TSHRHSP90AA1TDP1ALDH1A1KMT2A | |
| SCHEMBL27275673 | 0.79 | TDP1 (0.57) | TSHRTDP1ALDH1A1MEN1KMT2A | |
| Nitrobenzene SCHEMBL11708332 | 0.78 | ALDH1A1 (0.67) | TSHRTDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL23239 | 0.78 | — | — | |
| SCHEMBL3991309 | 0.78 | TSHR (0.61) | TSHRTDP1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5072053-A | Monomers for polybenzoxazoles | BAYER AKTIENGESELLSCHAFT (DE) | 1991-12-10 | — | — | US | disclosed |