SCHEMBL28201161

SCHEMBL28201161

COc1c[c]cc(N)c1C#N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.39
KDM4E B2RXH2 9/20 0.39
USP2 O75604 1/20 0.39
PRKCZ Q05513 1/20 0.36
MAPKAPK2 P49137 1/20 0.36
MAPT P10636 2/20 0.36
LMNA P02545 1/20 0.36
CYP2C9 P11712 1/20 0.36
ADORA1 P30542 4/20 0.35
HPGD P15428 4/20 0.35
ADORA2A P29274 3/20 0.35
TDP1 Q9NUW8 2/20 0.34
ADRA2B P18089 1/20 0.34
PTGS1 P23219 1/20 0.34
L3MBTL1 Q9Y468 2/20 0.33
HIF1A Q16665 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
MEN1 O00255 1/20 0.33
GLA P06280 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18889037 0.85 MAPT (0.41) ALDH1A1KDM4EUSP2PRKCZMAPT
SCHEMBL27956105 0.78 KDM4E (0.32) KDM4EADORA1ADORA2A
SCHEMBL17610729 0.76 LMNA (0.36) ALDH1A1KDM4EUSP2PRKCZMAPT
SCHEMBL5597488 0.72 ALDH1A1 (0.38) ALDH1A1MAPTTDP1ADRA2BPTGS1
SCHEMBL620373 0.72 ALDH1A1 (0.54) ALDH1A1KDM4EUSP2PRKCZMAPT
SCHEMBL28681440 0.71 L3MBTL1 (0.41) ALDH1A1KDM4EUSP2MAPTLMNA
SCHEMBL15647191 0.71 ALDH1A1 (0.46) ALDH1A1KDM4EUSP2PRKCZMAPKAPK2
SCHEMBL25329676 0.69 MAPT (0.43) ALDH1A1KDM4EUSP2PRKCZMAPKAPK2
SCHEMBL25330855 0.69 KDM4E (0.41) ALDH1A1KDM4EUSP2PRKCZMAPKAPK2
SCHEMBL27959747 0.68 ALDH1A1 (0.33) ALDH1A1KDM4EMAPTHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107573264-A A kind of preparation technology of the sulfonic acid chloride of 3 cyano group, 5 methoxybenzene 1 贵州大学 2018-01-12 CN claimed
CN-107573264-A A kind of preparation technology of the sulfonic acid chloride of 3 cyano group, 5 methoxybenzene 1 贵州大学 2018-01-12 CN disclosed